The fall of the Roman Empire in the fifth century A.D. saw the decline of the culture of ancient Rome. Papyrus became difficult to obtain, due to lack of contact with Egypt, and parchment, which had been used for centuries, began to be the main writing material.

Monasteries carried on the Latin writing tradition in the Western Roman Empire. Cassiodorus, in the monastery of Vivarium (established around 540), stressed the importance of copying texts[7]. St. Benedict of Nursia, in his Regula Monachorum (completed around the middle of the 6th century) later also promoted reading.[8] The Rule of St. Benedict (Ch. XLVIII), which set aside certain times for reading, greatly influenced the monastic culture of the Middle Ages, and is one of the reasons why the clergy were the predominant readers of books. The tradition and style of the Roman Empire still dominated, but slowly the peculiar medieval book culture emerged.

Before the invention and adoption of the printing press, almost all books were copied by hand, making books expensive and comparatively rare. Smaller monasteries usually had only some dozen books, medium sized perhaps a couple hundred. By the ninth century, larger collections held around 500 volumes; and even at the end of the Middle Ages, the papal library in Avignon and Paris library of Sorbonne held only around 2,000 volumes.[9]

Burgundian scribe (portrait of Jean Miélot, from Miracles de Notre Dame), 15th century. The depiction shows the room's furnishings, the writer's materials, equipment, and activity.

The scriptorium of the monastery was usually located over the chapter house. Artificial light was forbidden, for fear it may damage the manuscripts. There were five types of scribes:

• Copyists, who dealt with basic production and correspondence
• Calligraphers, who dealt in fine book production
• Correctors, who collated and compared a finished book with the manuscript from which it had been produced
• Rubricators, who painted in the red letters
• Illuminators, who painted illustrations

The bookmaking process was long and laborious. The parchment had to be prepared, then the unbound pages were planned and ruled with a blunt tool or lead, after which the text was written by the scribe, who usually left blank areas for illustration and rubrication. Finally the book was bound by the bookbinder.[10]

Desk with chained books in the Library of Cesena, Italy.

Different types of ink were known in antiquity, usually prepared from soot and gum, and later also from gall nuts and iron vitriol. This gave writing the typical brownish black color, but black or brown were not the only colours used. There are texts written in red or even gold, and different colours were used for illumination. Sometimes the whole parchment was coloured purple, and the text was written on it with gold or silver (eg Codex Argenteus).[11]

Irish monks introduced spacing between words in the seventh century. This facilitated reading, as these monks tended to be less familiar with Latin. However the use of spaces between words did not become commonplace before the 12th century. It has been argued,[12] that the use of spacing between words shows the transition from semi-vocalized reading into silent reading.

The first books used parchment or vellum (calf skin) for the pages. The book covers were made of wood and covered with leather. As dried parchment tends to assume the form before processing, the books were fitted with clasps or straps. During the later Middle Ages, when public libraries appeared, books were often chained to a bookshelf or a desk to prevent theft. The so called libri catenati were used up to 18th century.

At first books were copied mostly in monasteries, one at a time. With the rise of universities in the 13th century, the Manuscript culture of the time lead to an increase in the demand for books, and a new system for copying books appeared. The books were divided into unbound leaves (pecia), which were lent out to different copyists, so the speed of book production was considerably increased. The system was maintained by stationers guilds, which were secular, and produced both religious and non-religious material.[13]